Striker Keane was injured in the previous match against Hull City last Saturday and there were fears he would be sidelined again despite just returning from injury but he has been training this week.
Hughes has been missing through injury since late September and the left-back could return this weekend.
Giving an update on the other victims, Ryan said: “Greg [Cunningham] will be gone for a few weeks.
He has a slight hamstring strain but I hope it won’t last too long.
“Hughey is back on the field today, which is a big reward for us.
“Will Keane was on the pitch today.
He was fine after leaving the field against Hull, which was probably more of a precautionary measure.
“Jack Whatmough is doing rehab with the gym team on the lawn so we’re not far away.
” Ali [McCann] will be back after the international break, but we’re in a good position to have one or two guys back from injury.
They get there.
In the case of Calvin Ramsay, the Liverpool loanee has had a frustrating few months, suffering an issue in pre-season that has kept him sidelined for the entire campaign so far.
The 20-year-old has undergone rehabilitation at his parent club in recent months, but has now returned to training at Euxton.
Ryan said: “He’s healthy and ready.
He’s slowing down a few miles now, as you can imagine.
“I think he’s trained a little bit with Liverpool U21s and had some good sessions, but now we need to get him ready for what we think is Championship ready football.
“The truth is, it’s tough when you’re playing championship games, and what we need to prepare for Calvin now is to be tough enough to be able to handle him when he steps on the field.
” The manager has mentioned that next week’s Lancashire Senior Cup match against Accrington Stanley could be an opportunity for the right-back to get a few more minutes.
Meanwhile, North End will play two games before the international break: a trip to Coventry City on Saturday, then a Lancashire derby with Blackburn Rovers next Friday.
“They were all big games,” Ryan added.
“I think the level of performance deserves more points than we have, which is good and we will continue to have those performances.
“The more points you get on the board, the better.
We have a small target of how many points we want to score between now and the next international break, and hopefully we stay in the top half of the league, that will be the aim.
“If we keep doing what we’ve been doing the last few weeks in terms of performance and work ethic, we’ll be fine.
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